Drug receptor sites in the rabbit saphenous nerve
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چکیده
منابع مشابه
SUBTYPES OF α1-ADRENOCEPTORS IN RABBIT SAPHENOUS VEIN
We investigated the a,-adrenoceptor subtypes of rabbit saphenous vein which has a mixed functional population of α1 and α2 -adrenoceptors. Lateral saphenous veins were obtained from male rabbits weighing 3.20-4 kg, which were killed by overdose with pentobarbitone sodium (i.v. injection). They were easily dissected out and placed in cold, oxygenated modified Krebs-Henselite solution (Krebs)...
متن کاملExpression of endothelin receptor subtypes in rabbit saphenous vein.
Recent investigations have revealed the presence of vasoconstrictory endothelin (ET)-B receptors in several tissues, including the rabbit saphenous vein (RSV). To determine the nature of the ET binding sites in RSV, radioligand-receptor binding studies with selective ligands and Northern analyses with probes from the ET-A and ET-B receptor cDNAs were conducted. ET-1 inhibited 125I-ET-1 binding ...
متن کامل5-Hydroxytryptamine(1A) receptor activation enhances norepinephrine release from nerves in the rabbit saphenous vein.
Although serotonergic receptor agonists are known to modulate release of central serotonin, less is known about the ability of serotonin to alter neurotransmission in peripheral adrenergic nerves. The present study used field stimulation (40V, 0.7 ms duration, 1-16 Hz) to contract the rabbit saphenous vein, an effect that was abolished in the presence of tetrodotoxin and prazosin (10(-6) M), co...
متن کاملSaphenous nerve innervation of the medial ankle
BACKGROUND The distal saphenous nerve is commonly known to provide cutaneous innervation of the medial side of the ankle and distally to the base of the great toe. We hypothesize that the saphenous nerve innervates the periosteum of the medial malleolus and joint capsule. METHODS Five fresh limbs were dissected and the saphenous nerve was traced distally with magnification. The medial malleol...
متن کاملPOSSIBLE INVOLVEMENT OF GABAA RECEPTOR SITES IN CATALEPSY
The present work was performed to show the possible interaction of GAB A, and GABAB receptors in catalepsy. The following results were obtained: 1- Muscimol (MUS), a GABAA agonist, induced catalepsy. This effect was dose-dependent. Baclofen (BAC), a GABAB agonist, had no effect in this respect. 2- Catalepsy induced by muscimol was potentiated by pretreatment of animals with bicuculline (BI...
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ژورنال
عنوان ژورنال: British Journal of Pharmacology
سال: 1970
ISSN: 0007-1188
DOI: 10.1111/j.1476-5381.1970.tb10615.x